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Article

Nonlinear Modeling Reveals Novel Associations Between Genetically Predicted Protein Levels and Pancreatic Cancer Risk.

Molecular carcinogenesis - 1 Sept 2026

Zhu Jingjing, Wu Chong, Moaven Omeed, Yamazaki Hajime, Wei Yumeng, Dai Ben, Wu Lang

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) represents a highly fatal malignancy with a huge public health burden. There is a critical need to better understand its etiology for developing innovative strategies for effective prevention and treatment. Leveraging genetic variants as instrumental variables, Mendelian randomization and proteome-wide association study have identified dozens of protein biomarkers...

Topics

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Biomarkers, Tumor
Carcinoma, Pancreatic Ductal
Case-Control Studies
Genome-Wide Association Study
Nonlinear Dynamics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pancreatic Neoplasms

Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 42226484
DOI: 10.1002/mc.70135
PMCID: PMC13465998

Genes

PC
APOF
CCL15
CHIT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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