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Article

Circulating ACE2 levels and ACE I/D polymorphism in severe aortic stenosis.

Scientific reports - 1 Jun 2026

Mercean Denisa Bianca, Budişan Liviuţa, Pop Laura Ancuţa, Berindan-Neagoe Ioana, Pop Dana, Şerban Adela Mihaela, Melincovici Carmen Stanca, Mihu Carmen Mihaela

Abstract excerpt

The renin-angiotensin system (RAS) contributes to the fibro-calcific remodeling characteristic of aortic stenosis (AS). Although increased circulating ACE2 enzymatic activity has been reported in severe AS, data on circulating ACE2 protein concentration, ACE levels, and their relationship with ACE genetic variation remain limited. In this cross-sectional case-control study, 80 participants (40 severe AS, 40...

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Share to Angiotensin-Converting Enzyme 2
Share to Aortic Valve Stenosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Peptidyl-Dipeptidase A

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Source

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Identifiers

PMID: 42225887
DOI: 10.1038/s41598-026-55902-1
PMCID: PMC13462567

Genes

ACE
ACE2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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