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Dissecting the genetic relationship between severe mental disorders and autoimmune diseases.

Brain, behavior, and immunity - 1 Mar 2026

Wiström Erik D, Fuhrer Julian, Shadrin Alexey, Fominykh Vera, O'Connell Kevin S, Jaholkowski Piotr, Steen Nils Eiel, Stinson Sara E, Parekh Pravesh, Frei Oleksandr, Rødevand Linn, Parker Nadine, Haavik Jan, Djurovic Srdjan, Dale Anders M, Andreassen Ole A, Smeland Olav B

Abstract excerpt

Severe mental disorders have been linked to immune system dysfunction. While a genetic association between mental disorders and autoimmune diseases has been suggested, their genetic relationship remains incompletely understood. Utilizing a complementary set of statistical analyses, we conducted a comprehensive investigation of the genetic architecture between severe mental disorders (major depression (MD),...

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PMID: 41468944
DOI: 10.1016/j.bbi.2025.106249
PMCID: PMC13501237

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