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Saccharomyces cerevisiae β-Glucan Training Induces a Nonclassical PGE2-High/NO-Low Macrophage Phenotype in Response to Pseudomonas aeruginosa Exopolysaccharide.

Archivum immunologiae et therapiae experimentalis - 1 Jan 2026

Ciszek-Lenda Marta, Majka Grzegorz, Suski Maciej, Górska Sabina, Golińska Edyta, Siemińska Izabela, Olszanecki Rafał, Strus Magdalena, Marcinkiewicz Janusz

Abstract excerpt

Exopolysaccharide (EPS), a major constituent of Pseudomonas aeruginosa biofilms, protects bacteria from M1-macrophage-mediated clearance while promoting chronic inflammation. This study investigated how Saccharomyces cerevisiae β-glucan (BG)-induced macrophage training reshapes subsequent inflammatory and antimicrobial responses to EPS. Peritoneal macrophages from C57BL/6 mice were trained in vitro with BG and...

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PMID: 42220247
DOI: 10.2478/aite-2026-0014

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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