Staphylococcus aureus induced trained immunity in macrophages confers heterologous protection against gram-negative bacterial infection

Abstract excerpt

Summary Staphylococcus aureus can induce trained immunity in murine macrophages offering protection against repeat exposure during S. aureus skin infection. Here we demonstrate that S. aureus exposure can result in non-specific trained immunity in humans and mice, enhancing macrophage responsiveness and bacterial clearance in a heterologous challenge. In humans, the enhanced macrophage responsiveness was...

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