Article
Akkermansia muciniphila-induced trained immune phenotype increases bacterial intracellular survival and attenuates inflammation.
Communications biology - 16 Feb 2024
Peña-Cearra Ainize, Palacios Ainhoa, Pellon Aize, Castelo Janire, Pasco Samuel Tanner, Seoane Iratxe, Barriales Diego, Martin Jose Ezequiel, Pascual-Itoiz Miguel Ángel, Gonzalez-Lopez Monika, Martín-Ruiz Itziar, Macías-Cámara Nuria, Gutiez Naiara, Araujo-Aris Sarai, Aransay Ana Mª, Rodríguez Héctor, Anguita Juan, Abecia Leticia
Abstract excerpt
The initial exposure to pathogens and commensals confers innate immune cells the capacity to respond distinctively upon a second stimulus. This training capacity might play key functions in developing an adequate innate immune response to the continuous exposure to bacteria. However, the mechanisms involved in induction of trained immunity by commensals remain mostly unexplored. A. muciniphila represents an...
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