Article
Trained Immunity in Primary Sjögren's Syndrome: Linking Type I Interferons to a Pro-Atherogenic Phenotype.
Frontiers in immunology - 1 Jan 2022
Huijser Erika, van Helden-Meeuwsen Cornelia G, Grashof Dwin G B, Tarn Jessica R, Brkic Zana, Huisman Josje M A, Wahadat M Javad, van de Werken Harmen J G, Lopes Ana P, van Roon Joel A G, van Daele Paul L A, Kamphuis Sylvia, Ng Wan-Fai, Bekkering Siroon, Joosten Leo A B, Dik Willem A, Versnel Marjan A
Abstract excerpt
Background: Trained immunity - or innate immune memory - can be described as the long-term reprogramming of innate immune cells towards a hyperresponsive state which involves intracellular metabolic changes. Trained immunity has been linked to atherosclerosis. A subgroup of patients with primary Sjögren's syndrome (pSS) exhibits systemic type I interferon (IFN) pathway activation, indicating innate immune...
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