In vitro priming with Mycobacterium fortuitum induces trained immunity-associated phenotypes in caprine alveolar macrophages and enhances phagosomal maturation and antimicrobial functions upon homologous re-stimulation.

Abstract excerpt

Background: Trained immunity refers to the stimuli-induced epigenetic and metabolic reprogramming of innate immune cells, enabling enhanced non-specific responses upon secondary stimulation. Alveolar macrophages (AMs) constitute the primary immune barrier in the lung and represent a key target in enhancing protection against pulmonary pathogens. Methods: In this study, an in vitro priming-resting-re-stimulation...

Topics

• Animals
• Mycobacterium fortuitum
• Phagosomes
• Goats
• Trained Immunity