Phenotypic and epigenetic heterogeneity in FGFR2-fused glial and glioneuronal tumours.

doi:10.1111/nan.13014

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Article

Phenotypic and epigenetic heterogeneity in FGFR2-fused glial and glioneuronal tumours.

Neuropathology and applied neurobiology - 1 Dec 2024

Métais Alice, Dangouloff-Ros Volodia, Garcia Jeremy, Vannod-Michel Quentin, Csanyi Marie, Tauziède-Espariat Arnault, Appay Romain, Maurage Claude-Alain, Uro-Coste Emmanuelle, Meyronet David, Rigau Valérie, Rousseau Audrey, Chotard Guillaume, Hamelin Jocelyne, Pierron Gaelle, Colin Carole, Ollivier Morgan, Roques Margaux, Provost Corentin, Cottier Jean-Philippe, Pallud Johan, Chrétien Fabrice, Guida Lelio, Blauwblomme Thomas, Boddaert Nathalie, Varlet Pascale, Edjlali Myriam, Figarella-Branger Dominique

Abstract excerpt

AIMS: FGFR-fused central nervous system (CNS) tumours are rare and are usually within the glioneuronal and neuronal tumours or the paediatric-type diffuse low-grade glioma spectrum. Among this spectrum, FGFR2 fusion has been documented in tumours classified by DNA-methylation profiling as polymorphous low-grade neuroepithelial tumours of the young (PLNTY), a recently described tumour type. However, FGFR2 fusions...

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PMID: 39511841
DOI: 10.1111/nan.13014
PMCID: PMC11618513

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