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Article

KLK10 promotes the progression of KRAS mutant colorectal cancer via PAR1-PDK1-AKT signaling pathway.

Cell biology international - 1 Apr 2024

Wu Kun, Wu Boyu, Yan Kangpeng, Ding Qunhua, Miao Zhiguo

Abstract excerpt

Kirsten rat sarcoma virus (KRAS) gene mutation is common in colorectal cancer (CRC) and is often predictive of treatment failure and poor prognosis. To understand the mechanism, we compared the transcriptome of CRC patients with wild-type and mutant KRAS and found that KRAS mutation is associated with the overexpression of a secreted serine protease, kallikrein-related peptidase 10 (KLK10). Moreover, using in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 38115179
DOI: 10.1002/cbin.12113

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