Unstable tandem repeats in promoters confer transcriptional evolvability.

doi:10.1126/science.1170097

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Article

Unstable tandem repeats in promoters confer transcriptional evolvability.

Science (New York, N.Y.) - 29 May 2009

Vinces Marcelo D, Legendre Matthieu, Caldara Marina, Hagihara Masaki, Verstrepen Kevin J

Abstract excerpt

Relative to most regions of the genome, tandemly repeated DNA sequences display a greater propensity to mutate. A search for tandem repeats in the Saccharomyces cerevisiae genome revealed that the nucleosome-free region directly upstream of genes (the promoter region) is enriched in repeats. As many as 25% of all gene promoters contain tandem repeat sequences. Genes driven by these repeat-containing promoters...

Topics

Evolution, Molecular
Gene Expression Regulation, Fungal
Genome, Fungal
Mutation
Nucleosomes
Promoter Regions, Genetic
Saccharomyces cerevisiae
Tandem Repeat Sequences
Transcription, Genetic

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Identifiers

PMID: 19478187
DOI: 10.1126/science.1170097
PMCID: PMC3132887

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