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Article

Modulation of Homer1 EVH1 domain internal dynamics by putative autism-associated mutations.

FEBS letters - 1 Aug 2026

Farkas Fanni, Maruzs Brigitta, Kálmán Zsófia E, Klumpler Tomas, Batta Gyula, Péterfia Bálint, Gáspári Zoltán

Abstract excerpt

The EVH1 domain of the Homer1 scaffold protein interacts with the proline-rich region of Shank3, forming a key network within the postsynaptic density. While two mutations (M65I and S97L) in the EVH1 domain have been suggested to be associated with autism spectrum disorder, our results show that neither mutation has a substantial effect on the overall structure or the partner binding properties of Homer1....

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Identifiers

PMID: 42206738
DOI: 10.1002/1873-3468.70369
PMCID: PMC13502648

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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