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Article

Homer protein increases activation of Ca2+ sparks in permeabilized skeletal muscle.

The Journal of biological chemistry - 13 Feb 2004

Ward Christopher W, Feng Wei, Tu Jiangchen, Pessah Isaac N, Worley Paul K, Schneider Martin F

Abstract excerpt

Members of the Homer family of proteins are known to form multimeric complexes capable of cross-linking plasma membrane channels (e.g. metabotropic glutamate receptor) and intracellular Ca2+ release channels (e.g. inositol trisphosphate receptor) in neurons, which potentiates Ca2+ release. Recent work has demonstrated direct interaction of Homer proteins with type 1 and type 2 ryanodine receptor (RyR) isoforms....

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Identifiers

PMID: 14660561
DOI: 10.1074/jbc.M311422200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Homer protein increases activation of Ca2+ sparks in permeabilized skeletal muscle.PMID 14660561Read ↗

Molecular characterisation of two structurally distinct groups of human homers, generated by extensive alternative splicing.Semantic proximity Read ↗

Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors.Semantic proximity Read ↗

Expression and regulation of Homer in human skeletal muscle during neuromuscular junction adaptation to disuse and exerciseSemantic proximity Read ↗

Alternative splicing of RyR1 alters the efficacy of skeletal EC couplingSemantic proximity Read ↗

Effect of oxidative stress on homer scaffolding proteins.Semantic proximity Read ↗

AAV-mediated hippocampal expression of short and long Homer 1 proteins differentially affect cognition and seizure activity in adult rats.Semantic proximity Read ↗

An α-helical C-terminal tail segment of the skeletal L-type Ca2+ channel β1a subunit activates ryanodine receptor type 1 via a hydrophobic surface.Semantic proximity Read ↗

Effects of coexpression with Homer isoforms on the function of metabotropic glutamate receptor 1alpha.Semantic proximity Read ↗

Modulation of Homer1 EVH1 domain internal dynamics by putative autism-associated mutations.Semantic proximity Read ↗

A variably spliced region in the type 1 ryanodine receptor may participate in an inter-domain interaction.Semantic proximity Read ↗

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