Article
Allele-specific antibodies to Plasmodium vivax merozoite surface protein-1: prevalence and inverse relationship to haemoglobin levels during infection.
Malaria journal - 16 Nov 2016
Sepúlveda Nuno, Morais Cristiane Guimarães, Mourão Luiza Carvalho, Freire Matheus França, Fontes Cor Jesus F, Lacerda Marcus Vinícius G, Drakeley Chris J, Braga Érika Martins
Abstract excerpt
BACKGROUND: Antigenic polymorphisms are considered as one of the main strategies employed by malaria parasites to escape from the host immune responses after infections. Merozoite surface protein-1 (MSP-1) of Plasmodium vivax, a promising vaccine candidate, is a highly polymorphic protein whose immune recognition is not well understood. METHODS AND RESULTS: The IgG responses to conserved (MSP-119) and polymorphic...
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