Article
Assessing the effect of parasite antigen genetic diversity on performance of Plasmodium vivax serological exposure markers for malaria: a multicentre observational diagnostic accuracy study.
The Lancet. Microbe - 1 Jun 2026
Bareng Alison Paolo N, Wu Kenneth W, Takashima Eizo, Argyropoulos Dionne C, Smith Lauren, Naung Myo T, Mazhari Ramin, Schoffer Kael, Kiernan-Walker Nicholas, Abraham Anju, Lamont Macie, Mehra Somya, Lim Pailene S, Sattabongkot Jetsumon, Monteiro Wuelton, Lacerda Marcus, Healer Julie, Chitnis Chetan E, Tham Wai-Hong, Tsuboi Takafumi, Mueller Ivo, Barry Alyssa E, Longley Rhea J
Abstract excerpt
BACKGROUND: Plasmodium vivax poses a major obstacle to malaria elimination because this parasite can lie dormant in the liver for weeks to months before reactivating and causing a relapse of infection. These dormant forms (hypnozoites) cannot be detected using standard diagnostics, but P vivax exposure in the previous 9 months and, by proxy, hypnozoite carriage, can be inferred using serological markers. In this...
Topics
- Plasmodium vivax
- Humans
- Malaria, Vivax
- Antigens, Protozoan
- Genetic Variation
- Brazil
- Haplotypes
- Thailand