Article
Upsurge of pneumococcal clade I-α/CC180 serotype 3 and its association with a LytA mutation linked to immune evasion and disease potential: an observational and experimental study.
The Lancet. Microbe - 1 Jul 2026
Pérez-García Covadonga, Sempere Julio, Llamosí Mirella, González-Díaz Aída, de Miguel Sara, Vidal-Alcántara Erick Joan, Sanz Juan Carlos, García Ernesto, Brueggemann Angela B, Ardanuy Carmen, Domenech Mirian, Yuste Jose
Abstract excerpt
BACKGROUND: Streptococcus pneumoniae serotype 3 is one of the most prevalent serotypes that cause invasive pneumococcal disease (IPD) in children and adults worldwide. Serotype 3 is associated with vaccine failures and breakthrough episodes in children vaccinated with 13-valent pneumococcal conjugate vaccine (PCV13). In this study, we aimed to investigate potential genetic mechanisms that could explain the...
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