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Article

Innate immunogenetic synergy between KIR and Neanderthal-derived OAS variants predicts COVID-19 outcomes.

PloS one - 1 Jan 2026

Akin Hasan Yalim, Tuncali Timur, Gencer Emine Begum, Cengiz Seval Guldane, Saricaoglu Elif Mukime, Gulten Ezgi, Akdemir Kalkan Irem, Cinar Gule, Memikoglu Osman, Anliacik Ridvan Goksel, Anliacik Ezgi, Karaagaoglu Ergun, Dalva Klara, Beksac Meral

Abstract excerpt

BACKGROUND: Genetic factors modulate the progression of coronavirus disease 2019 (COVID-19), but interactions between innate immune gene variants remain incompletely understood. Prior work identified Killer Immunoglobulin-like Receptor (KIR) genotypes and Neanderthal-introgressed OAS1/2/3 haplotypes as key modulators of disease severity. Given these parallel findings, we aimed to evaluate the synergistic impact...

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Share to 2',5'-Oligoadenylate Synthetase
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Haplotypes

Share to Immunity, Innate

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Share to Polymorphism, Single Nucleotide

Share to Receptors, KIR

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Source

Open in PubMed Open full text

Identifiers

PMID: 42201890
DOI: 10.1371/journal.pone.0345137
PMCID: PMC13215513

Genes

OAS1
APOE
DPP4
IFITM3
TLR7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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