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Article

Activating Killer-Cell Immunoglobulin-Like Receptors Are Associated With the Severity of Coronavirus Disease 2019.

The Journal of infectious diseases - 15 Jul 2021

Bernal Enrique, Gimeno Lourdes, Alcaraz María J, Quadeer Ahmed A, Moreno Marta, Martínez-Sánchez María V, Campillo José A, Gomez Jose M, Pelaez Ana, García Elisa, Herranz Maite, Hernández-Olivo Marta, Martínez-Alfaro Elisa, Alcaraz Antonia, Muñoz Ángeles, Cano Alfredo, McKay Matthew R, Muro Manuel, Minguela Alfredo

Abstract excerpt

BACKGROUND: Etiopathogenesis of the clinical variability of the coronavirus disease 2019 (COVID-19) remains mostly unknown. In this study, we investigate the role of killer cell immunoglobulin-like receptor (KIR)/human leukocyte antigen class-I (HLA-I) interactions in the susceptibility and severity of COVID-19. METHODS: We performed KIR and HLA-I genotyping and natural killer cell (NKc) receptors...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33928374
DOI: 10.1093/infdis/jiab228
PMCID: PMC8135764

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