HLA-DPB1*13:01 associates with enhanced, and KIR2DS4*001 with diminished protection from developing severe COVID-19.

doi:10.1111/tan.15251

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

HLA-DPB113:01 associates with enhanced, and KIR2DS4001 with diminished protection from developing severe COVID-19.

HLA - 1 Jan 2024

Farias Ticiana D J, Brugiapaglia Silvia, Croci Susanna, Magistroni Paola, Curcio Claudia, Zguro Kristina, Fallerini Chiara, Fava Francesca, Pettini Francesco, Kichula Katherine M, Pollock Nicholas R, Font-Porterias Neus, Palmer William H, Marin Wesley M, Baldassarri Margherita, Bruttini Mirella, Hollenbach Jill A, Hendricks Audrey E, Meloni Ilaria, Novelli Francesco, Renieri Alessandra, Furini Simone, Norman Paul J, Amoroso Antonio

Abstract excerpt

Extreme polymorphism of HLA and killer-cell immunoglobulin-like receptors (KIR) differentiates immune responses across individuals. Additional to T cell receptor interactions, subsets of HLA class I act as ligands for inhibitory and activating KIR, allowing natural killer (NK) cells to detect and...

Topics

Humans
COVID-19
SARS-CoV-2
Alleles
Receptors, KIR
Genotype
Autoantibodies
HLA-DP beta-Chains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Open in PubMed Open full text

Identifiers

PMID: 37850268
DOI: 10.1111/tan.15251
PMCID: PMC10873037

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-37850268-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.