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Article

Epistatic pathways can drive HIV-1 escape from integrase strand transfer inhibitors.

Science advances - 1 Mar 2024

Hikichi Yuta, Grover Jonathan R, Schäfer Alicia, Mothes Walther, Freed Eric O

Abstract excerpt

People living with human immunodeficiency virus (HIV) receiving integrase strand transfer inhibitors (INSTIs) have been reported to experience virological failure in the absence of resistance mutations in integrase. To elucidate INSTI resistance mechanisms, we propagated HIV-1 in the presence of escalating concentrations of the INSTI dolutegravir. HIV-1 became resistant to dolutegravir by sequentially acquiring...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38427738
DOI: 10.1126/sciadv.adn0042
PMCID: PMC10906922

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