Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pan-filovirus activity of an IGF2-fused monoclonal antibody: Impairment by IGF1R cross-engagement and rescue via IGF2 Y27L mutation.

Virus research - 1 Jul 2026

Hu Wen, Wu Xiaonan, Zhang Yuting, Zhao Siyu, He Junjie, Li Xuanyi, He Muyang, Wang Jing, Luo Longlong, Xiao He, Li Xinying, Liu Chenghua, Huang Weijin, Wang Youchun, Qiao Chunxia, Feng Jiannan, Wen Yan, Chen Guojiang

Abstract excerpt

BACKGROUND: Filoviruses (Ebola and Marburg) cause severe high-mortality infectious diseases. Neutralizing antibodies represent promising antiviral candidates, but broadly reactive antibodies against multiple filoviruses are rare. Antibody-ligand fusion strategies that combine conserved glycoprotein-targeting antibodies with IGF2R ligands can mediate endosomal antibody delivery. Previously, we showed that an...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Monoclonal
Share to Antibodies, Neutralizing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Antibodies, Viral

Share to Insulin-Like Growth Factor II

Share to Receptor, IGF Type 1

Share to Receptors, Somatomedin

Share to Recombinant Fusion Proteins

Share to Virus Internalization

Source

Open in PubMed Open full text

Identifiers

PMID: 42191025
DOI: 10.1016/j.virusres.2026.199755
PMCID: PMC13234713

Genes

IGF2
IGF1R
NPC2
IGF2R

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pan-filovirus activity of an IGF2-fused monoclonal antibody: Impairment by IGF1R cross-engagement and rescue via IGF2 Y27L mutation.PMID 42191025Read ↗

A specific anti-IFITM2 antibody bars the way to SARS-CoV-2 entry into host cellsSemantic proximity Read ↗

Chimeric Filoviruses for Identification and Characterization of Monoclonal AntibodiesSemantic proximity Read ↗

Human antibody cocktail deploys multiple functions to confer pan-ebolavirus protectionSemantic proximity Read ↗

Generation and Selection of a Panel of Pan-Filovirus Single-Chain Antibodies using Cell-Free Ribosome DisplaySemantic proximity Read ↗

Structural Basis of Pan-Ebolavirus Neutralization by an Antibody Targeting the Glycoprotein Fusion LoopSemantic proximity Read ↗

Macaque Monoclonal Antibodies Targeting Novel Conserved Epitopes within Filovirus GlycoproteinSemantic proximity Read ↗

Rational design of next-generation filovirus vaccines through glycoprotein stabilization, nanoparticle display, and glycan modificationSemantic proximity Read ↗

Functional assessment and structural basis of antibody binding to human papillomavirus capsidSemantic proximity Read ↗

A Dual-Approach Strategy to Optimize the Safety and Efficacy of Anti-Zika Virus Monoclonal Antibody TherapeuticsSemantic proximity Read ↗

Exosomes secreted by CSFV-infected cells evade neutralizing antibody to activate innate immune responses and establish productive infection in recipient cellsSemantic proximity Read ↗

High Affinity Promotes Internalization of Engineered Antibodies Targeting FGFR1Semantic proximity Read ↗

Cell type-specific delivery by modular envelope designSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.