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Chimeric Filoviruses for Identification and Characterization of Monoclonal Antibodies

28 Jan 2016

Abstract excerpt

UNLABELLED: Recent experiments suggest that some glycoprotein (GP)-specific monoclonal antibodies (MAbs) can protect experimental animals against the filovirus Ebola virus (EBOV). There is a need for isolation of MAbs capable of neutralizing multiple filoviruses. Antibody neutralization assays for filoviruses frequently use surrogate systems such as the rhabdovirus vesicular stomatitis Indiana virus (VSV),...

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PMID: 26819310
DOI: 10.1128/jvi.00101-16

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