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Article

Identification of end-stage renal disease-associated loci in X chromosome: an X chromosome-wide association study.

MedScience - 1 Apr 2026

Zhou Xiaohong, Shi Dianchun, Li Ming, Liu Yibin, Ye Zhiming, Chen Wei, Wang Meng, Fu Dongying, Wang Yanna, Gan Hua, Fu Ping, Tan Xiaojun, Kong Yaozhong, Chen Jihong, Zhao Jinghong, Yu Xueqing, Liu Jianjun

Abstract excerpt

X-chromosomal genetic variants have been understudied in end-stage renal disease (ESRD), which holds the promise to provide valuable insights into sexually dimorphic traits and diseases. Here we performed an X chromosome-wide association study (XWAS) in a Chinese cohort (N = 2750), comprising 1489 cases with ESRD and 1261 controls, to identify locus associated with ESRD risk. One locus showing a consistent effect...

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Share to Chromosomes, Human, X
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

Share to Kidney Failure, Chronic

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Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 42189395
DOI: 10.1007/s11684-026-1205-3

Genes

SYTL4
COL4A5
CSTF2
NOX1
PCDH19
TSPAN6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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