Article
A genome-wide association study in Chinese men identifies three risk loci for non-obstructive azoospermia.
Nature genetics - 25 Dec 2011
Hu Zhibin, Xia Yankai, Guo Xuejiang, Dai Juncheng, Li HongGang, Hu Hongliang, Jiang Yue, Lu Feng, Wu Yibo, Yang Xiaoyu, Li Huizhang, Yao Bing, Lu Chuncheng, Xiong Chenliang, Li Zheng, Gui Yaoting, Liu Jiayin, Zhou Zuomin, Shen Hongbing, Wang Xinru, Sha Jiahao
Abstract excerpt
Non-obstructive azoospermia (NOA) is one of the most severe forms of male infertility. Its pathophysiology is largely unknown, and few genetic influences have been defined. To identify common variants contributing to NOA in Han Chinese men, we performed a three-stage genome-wide association study of 2,927 individuals with NOA and 5,734 controls. The combined analyses identified significant (P < 5.0 × 10(-8))...
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