Deep phenotyping of skin tissue remodeling in patients with systemic sclerosis treated with CD19-CAR T cells.

doi:10.1038/s41467-026-72817-7

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Article

Deep phenotyping of skin tissue remodeling in patients with systemic sclerosis treated with CD19-CAR T cells.

Nature communications - 23 May 2026

Rius Rigau Aleix, Xu Meilin, Liu Ziyuan, Chenguiti Fakhouri Sara, Auth Janina, Garantziotis Panagiotis, Zoli Andrea, Selvaraju Manoj Kumar, Raimondo Maria Gabriella, Tur Carlo, Filla Tim, Gehringer Paula, Eckstein Markus, Müller Fabian, Atzinger Armin, Ronicke Moritz, Ekici Arif, Schmid Rafael, Wirsching Andreas, Hagen Melanie, Böltz Sebastian, Krickau Tobias, Horch Raymund E, Berking Carola, Grieshaber-Bouyer Ricardo, Ramming Andreas, Gupta Pooja, Bozec Aline, Mackensen Andreas, Distler Jörg Hw, Schett Georg, Li Yi-Nan, Bergmann Christina

Abstract excerpt

Systemic sclerosis (SSc) is an autoimmune disease characterized by vasculopathy and fibrotic remodeling of the skin and internal organs. Fibrotic tissue changes are considered hardly reversible with current therapies, suggesting that new strategies are required to modulate the disease-associated molecular and cellular phenotype to enable regeneration of affected tissues. Here, analyzing skin biopsy samples from...

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Identifiers

PMID: 42177178
DOI: 10.1038/s41467-026-72817-7
PMCID: PMC13201536

Genes

CD19

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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