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Article

Circulating proteins and risk of small vessel stroke: A two-sample Mendelian randomization study.

Medicine - 22 May 2026

Gao Ziwei, Xu Yawen, Chen Yue, Kang Dezhi, Lin Yuanxiang, Yao Peisen

Abstract excerpt

To identify promising circulating biomarkers for small vessel stroke (SVS), we applied Mendelian randomization (MR) design to systematically screen circulating proteins for potential development of SVS. We performed two-sample MR analyses to estimate the associations between 4782 human circulating proteins (including immunity-related proteins) and risk of SVS. We selected 359 circulating proteins in MR estimation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42175399
DOI: 10.1097/MD.0000000000048898
PMCID: PMC13200920

Genes

GRAMD1C
PTGR1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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