Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Anion-exchange chromatography mass spectrometry provides extensive coverage of primary metabolic pathways revealing altered metabolism in IDH1 mutant cells.

Communications biology - 20 May 2020

Walsby-Tickle John, Gannon Joan, Hvinden Ingvild, Bardella Chiara, Abboud Martine I, Nazeer Areesha, Hauton David, Pires Elisabete, Cadoux-Hudson Tom, Schofield Christopher J, McCullagh James S O

Abstract excerpt

Altered central carbon metabolism is a hallmark of many diseases including diabetes, obesity, heart disease and cancer. Identifying metabolic changes will open opportunities for better understanding aetiological processes and identifying new diagnostic, prognostic, and therapeutic targets. Comprehensive and robust analysis of primary metabolic pathways in cells, tissues and bio-fluids, remains technically...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line, Tumor
Share to Chromatography, Ion Exchange

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glioblastoma

Share to Glutarates

Share to Isocitrate Dehydrogenase

Share to Ketoglutaric Acids

Share to Metabolic Networks and Pathways

Share to Tandem Mass Spectrometry

Source

Open in PubMed Open full text

Identifiers

PMID: 32433536
DOI: 10.1038/s42003-020-0957-6
PMCID: PMC7239943

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Anion-exchange chromatography mass spectrometry provides extensive coverage of primary metabolic pathways revealing altered metabolism in IDH1 mutant cells.PMID 32433536Read ↗

Integrated Metabolomics and Lipidomics Analyses Reveal Metabolic Reprogramming in Human Glioma with IDH1 MutationSemantic proximity Read ↗

Methodological Approaches for Assessing Metabolomic Changes in Glioblastomas.Semantic proximity Read ↗

Metabolic adaptations in cancers expressing isocitrate dehydrogenase mutations.Semantic proximity Read ↗

Profiling the Effect of Targeting Wild Isocitrate Dehydrogenase 1 (IDH1) on the Cellular Metabolome of Leukemic Cells.Semantic proximity Read ↗

Profiling The Effect of Targeting Wild Isocitrate Dehydrogenase 1 (IDH1) on the Cellular Metabolome of Leukemic CellsSemantic proximity Read ↗

Altered cancer cell metabolism in gliomas with mutant IDH1 or IDH2.Semantic proximity Read ↗

A map of the altered glioma metabolism.Semantic proximity Read ↗

Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome.Semantic proximity Read ↗

Metabolic checkpoint CPS1 sustains TCA anaplerosis via urea cycle in IDH-mutant gliomas.Semantic proximity Read ↗

Cancer-Associated IDH1 Promotes Growth and Resistance to Targeted Therapies in the Absence of Mutation.Semantic proximity Read ↗

Tissue metabolites in diffuse glioma and their modulations by IDH1 mutation, histology, and treatment.Semantic proximity Read ↗

Integrated multi-omics reveals anaplerotic insufficiency in methylmalonyl-CoA mutase deficiencySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.