Mutations of the lon protease and tryptophan operon gene trpA in Edwardsiella tarda regulate colonization and pathogenesis in olive flounder fish.

Abstract excerpt

Edwardsiella tarda is a severe aquaculture and zoonosis pathogen that infects a wide range of fish, especially the Oliver flounder fish. Investigation of its pathogenetic mechanisms is important for developing an effective protective agent, such as a vaccine or antibiotics. In this study, we characterized the involvement of two target genes, lon protease and tryptophan operon gene trpA, in the virulence and...

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