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Article

A Mitoxyperilysis-Related Single-Cell and Machine-Learning Framework Defines an Immune-Cold Melanoma Phenotype and a Robust Prognostic Signature.

Human mutation - 1 Jan 2026

Zhou Yuze, Fang Jiahong, Fei Lujing, Li Huixian, Xu Xiaolong, Xie Jiaheng, Qi Min

Abstract excerpt

Mitoxyperilysis is a mitochondria-dependent membrane lysis process driven by innate immune and metabolic cues, yet its clinical relevance in melanoma remains unclear. We analyzed single-cell RNA-seq data (GSE215120) to quantify a mitoxyperilysis-related score (MRS), resolve cell-type heterogeneity, and compare predicted cell-cell communication between MRS-high and MRS-low tumor states. MRS was robust across...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42170303
DOI: 10.1155/humu/9909803
PMCID: PMC13189447

Genes

GPR143

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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