LDCT combined with serum miR-4638-3p expression enhances NSCLC diagnostic efficacy and rs6601178 polymorphism susceptibility association.

doi:10.1186/s13019-026-04210-w

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Article

LDCT combined with serum miR-4638-3p expression enhances NSCLC diagnostic efficacy and rs6601178 polymorphism susceptibility association.

Journal of cardiothoracic surgery - 21 May 2026

Meng Zeyu, Xue Ting, Jiang Bo

Abstract excerpt

BACKGROUND: Despite reducing lung cancer mortality, low-dose computed tomography (LDCT) is limited by a high false positive rate. This study integrates serum miR-4638-3p with LDCT to assess its diagnostic value in non-small cell lung cancer (NSCLC), explore miR-4638-3p's mechanisms, and analyze the rs6601178 polymorphism's association with NSCLC susceptibility. METHODS: Participants comprised 152 healthy controls...

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PMID: 42169143
DOI: 10.1186/s13019-026-04210-w
PMCID: PMC13371660

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PTEN
CCK

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