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A clinically effective model based on cell-free DNA methylation and low-dose CT for risk stratification of pulmonary nodules

27 Sept 2024

Abstract excerpt

Accurate, non-invasive, and cost-effective tools are needed to assist pulmonary nodule diagnosis and management due to increasing detection by low-dose computed tomography (LDCT). We perform genome-wide methylation sequencing on malignant and non-malignant lung tissues and designed a panel of 263 differential DNA methylation regions, which is used for targeted methylation sequencing on blood cell-free DNA (cfDNA)...

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PMID: 39341207
DOI: 10.1016/j.xcrm.2024.101750

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