Article
Genetic insights into pulmonary nodules and lung cancer: similarities and differences revealed by GWAS studies.
Human molecular genetics - 15 Apr 2026
Zhang Jiahao, Zhu Chen, Li Qiao, Song Ci, Zhu Meng, Ji Chen, Wu Lili, Zhu Lingying, Lu Jing, Zhang Qun, Wu Feiyun, Jin Chen, Mou Yuanlin, Zhu Mingxuan, Cai Jiaying, Zhang Caochen, Fu Yating, Gong Linnan, Hang Dong, Dai Juncheng, Jiang Yue, Shi Lei, Jin Guangfu, Hu Zhibin, Shen Hongbing, Du Lingbin, Ma Hongxia
Abstract excerpt
The widespread implementation of low-dose computed tomography (LDCT) has markedly increased the detection of pulmonary nodules, yet their genetic determinants remain poorly understood. We conducted a genome-wide association study (GWAS) of 36 175 LDCT-screened individuals from Zhejiang and Jiangsu provinces in China, assessing fourteen pulmonary nodule phenotypes defined using a convolutional neural network-based...
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