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Article

Impact of population-specific pharmacogenomic variants on drug dosing in ICU patients.

The pharmacogenomics journal - 21 May 2026

Rostami Mahboubeh R, Rodriguez-Flores Juan, Ait Hssain Ali, Al Shakaki Alya, Khan Huda, Vakayil Muneera, Karic Edin, Elhamid Maha, Gamal Al Tawil Lubna, Mezey Jason G, Robay Amal, Crystal Ronald G

Abstract excerpt

Intensive care units (ICU) patients are highly vulnerable to inaccurate drug dosing. Pharmacogenomics (PGx) studies the role of inherited genetic variation in drug metabolism and dose efficacy. To assess the prevalence of PGx variants that may influence therapeutic effect in the ICU, we carried out whole genome sequencing (WGS) of 210 Qataris in ICU care at Hamad Medical Corporation (HMC), Doha, Qatar and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42168146
DOI: 10.1038/s41397-026-00415-3
PMCID: PMC13193941

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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