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Article

Do all colorectal mucinous adenocarcinomas arise via the serrated neoplasia pathway?

The journal of pathology. Clinical research - 1 May 2026

Vos Anne-Marie, van Zwam Peter H, Rutgers Natasja, van Vliet Shannon, Vink-Börger Elisa, van der Post Rachel S, Simmer Femke, Nagtegaal Iris D

Abstract excerpt

Colorectal mucinous adenocarcinomas (MACs) and serrated adenocarcinomas (SACs) demonstrate considerable overlap in morphological and molecular features, suggesting a spectrum rather than two distinct tumour types. This study investigates the presence of serrated morphological features, precursors, and molecular features in a large cohort of MAC. The study includes 698 MAC collected via the Dutch nationwide...

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Identifiers

PMID: 42166218
DOI: 10.1002/2056-4538.70092

Genes

BRAF
KRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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