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Article

Serrated colorectal cancer: Molecular classification, prognosis, and response to chemotherapy.

World journal of gastroenterology - 7 Apr 2016

Murcia Oscar, Juárez Miriam, Hernández-Illán Eva, Egoavil Cecilia, Giner-Calabuig Mar, Rodríguez-Soler María, Jover Rodrigo

Abstract excerpt

Molecular advances support the existence of an alternative pathway of colorectal carcinogenesis that is based on the hypermethylation of specific DNA regions that silences tumor suppressor genes. This alternative pathway has been called the serrated pathway due to the serrated appearance of tumors in histological analysis. New classifications for colorectal cancer (CRC) were proposed recently based on genetic...

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Identifiers

PMID: 27053844
DOI: 10.3748/wjg.v22.i13.3516
PMCID: PMC4814638

Genes

BRAF
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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