Article
Tbx1 heterozygosity in the oligodendrocyte lineage shifts myelinated axon composition in the mouse fimbria without behavioral impairments.
Molecular brain - 20 May 2026
Wells Anne Marie, Tanifuji Takaki, Takano Takeshi, Endo Arumu, Kang Gina, Esparza Marisa, Shi Qian, Bhat Manzoor A, Hiroi Noboru
Abstract excerpt
Constitutive heterozygosity of Tbx1, a T-box transcription factor gene located within the 22q11.2 deletion region, results in behavioral deficits and altered composition of myelinated axons in the fimbria, together with reduced levels of an oligodendrocyte precursor cell (OPC) marker, in mice. However, the cellular origins of these effects and the extent to which axonal changes causally contribute to behavioral...
Topics
- Animals
- Axons
- Heterozygote
- Cell Lineage
- Oligodendroglia
- Male
- T-Box Domain Proteins
- Behavior, Animal
- Nerve Fibers, Myelinated
- Myelin Sheath
- Receptor, Platelet-Derived Growth Factor alpha
- Phenotype
- Mice, Inbred C57BL