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Article

Tbx1: identification of a 22q11.2 gene as a risk factor for autism spectrum disorder in a mouse model.

Human molecular genetics - 15 Dec 2011

Hiramoto Takeshi, Kang Gina, Suzuki Go, Satoh Yasushi, Kucherlapati Raju, Watanabe Yasuhiro, Hiroi Noboru

Abstract excerpt

Although twin studies indicate clear genetic bases of autism spectrum disorder (ASD), the precise mechanisms through which genetic variations causally result in ASD are poorly understood. Individuals with 3 Mb and nested 1.5 Mb hemizygosity of the chromosome 22q11.2 represent genetically identifiable cases of ASD. However, because more than 30 genes are deleted even in the minimal deletion cases of 22q11.2...

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Identifiers

PMID: 21908517
DOI: 10.1093/hmg/ddr404
PMCID: PMC3221538

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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