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Article

Recurrent SWI/SNF Deficiency Defines a Subset of Peripheral T-Cell Lymphoma With Distinct Clinicopathologic Features.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jul 2026

Bledsoe Jacob R, Ferry Judith A, Li Jingwei, Sassoon Aaron, Stonhill Miekan A, Siegele Bradford, Liang Xiayuan, Dalton Justin, Mochel Mark C, Ivashkevich Yana, Johari Vandita, Sadigh Sam, Selove William, Sood Sadhika, Ward Nicholas, Woda Bruce, Degar Barbara, Feraco Angela M, Rowe Jared, Davies Kimberly, Al-Ibraheemi Alyaa, Amador Catalina, Kovach Alexandra E, Fleming Mark D, Harris Marian H, Tsai Harrison K

Abstract excerpt

Peripheral T-cell lymphoma, not otherwise specified (PTCL, NOS) rarely occurs in pediatric and young adult populations, where little is known about its clinicopathologic and molecular features. We characterized 16 cases of PTCL, NOS diagnosed in patients ≤21 years old. Seven (44%) cases demonstrated SMARCB1/INI1 loss by immunohistochemistry and SMARCB1/INI1 alterations by next-generation sequencing, including...

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Topics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Chromosomal Proteins, Non-Histone

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Source

Identifiers

PMID: 42162914
DOI: 10.1016/j.modpat.2026.101015

Genes

SMARCB1
CD4
TBX21
CDKN2A
GATA3
PTEN
SMARCE1
TET2
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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