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Article

Clinicopathologic and Molecular Characterization of SMARCB1-Deificient Sinonasal Carcinomas -A Systematic Study from a Single Institution Cohort.

Head and neck pathology - 14 May 2025

Li Qinyuan, Abi-Saab Tarek, Prilutskiy Andrey, Horner Vanessa, Frater-Rubsam Leah, Peng Yajing, Huang Wei, Kimple Randall J, Harari Paul M, Lloyd Ricardo V, Hu Rong

Abstract excerpt

BACKGROUND: SMARCB1-deficient and SMARCA4-deficient sinonasal carcinomas are rare, with only a few systematic studies available in the literature. Secondary EWSR1 gene abnormalities have been reported in SMARCB1-deficient tumors. This study aimed to systematically investigate SWI/SNF complex-deficient sinonasal carcinomas in a single-institution cohort, perform clinicopathologic characterization, and explore the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40366517
DOI: 10.1007/s12105-025-01788-w
PMCID: PMC12078905

Genes

SMARCB1
EWSR1
SMARCA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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