Cerebral tryptophan metabolism and outcome of tuberculous meningitis: an observational cohort study.

doi:10.1016/S1473-3099(18)30053-7

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Article

Cerebral tryptophan metabolism and outcome of tuberculous meningitis: an observational cohort study.

The Lancet. Infectious diseases - 1 May 2018

van Laarhoven Arjan, Dian Sofiati, Aguirre-Gamboa Raúl, Avila-Pacheco Julian, Ricaño-Ponce Isis, Ruesen Carolien, Annisa Jessi, Koeken Valerie A C M, Chaidir Lidya, Li Yang, Achmad Tri Hanggono, Joosten Leo A B, Notebaart Richard A, Ruslami Rovina, Netea Mihai G, Verbeek Marcel M, Alisjahbana Bachti, Kumar Vinod, Clish Clary B, Ganiem A Rizal, van Crevel Reinout

Abstract excerpt

BACKGROUND: Immunopathology contributes to the high mortality of tuberculous meningitis, but the biological pathways involved are mostly unknown. We aimed to compare cerebrospinal fluid (CSF) and serum metabolomes of patients with tuberculous meningitis with that of controls without tuberculous meningitis, and assess the link between metabolite concentrations and mortality. METHODS: In this observational cohort...

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PMID: 29395996
DOI: 10.1016/S1473-3099(18)30053-7

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