Article
Akkermansia muciniphila attenuates intervertebral disc degeneration via extracellular vesicle-mediated delivery of the effector protein B2UKX5.
Bone research - 20 May 2026
Guan Zhe, Li Xiaoxue, Chen Yixiao, Zhu Sheng, Wen Jie, Zhou Hongliang, Chen Chunyuan, Liu Jianghua, Zhu Guoqiang, Pang Zhilin, Liu Yiwei, Jin Ling, Zeng Shiyu, Luo Yi, Gong Xiaoxiao, Yang Yu, Chen Ya, Wu Yang, Wan Meidan, Yin Hao, Zhou Yong, Wang Zhenxing, Xie Hui
Abstract excerpt
Low back pain is a leading cause of global disability, with intervertebral disc degeneration (IVDD) as a primary contributor. Emerging evidence suggests a link between gut microbiota and disc health, yet the underlying mechanisms remain unclear. Through Mendelian randomization and a clinical cohort analysis, we identified a causal inverse relationship between Akkermansia muciniphila (Akk) abundance and IVDD risk,...
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