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Article

Targeted deletion of collagen V in tendons and ligaments results in a classic Ehlers-Danlos syndrome joint phenotype.

The American journal of pathology - 1 May 2015

Sun Mei, Connizzo Brianne K, Adams Sheila M, Freedman Benjamin R, Wenstrup Richard J, Soslowsky Louis J, Birk David E

Abstract excerpt

Collagen V mutations underlie classic Ehlers-Danlos syndrome, and joint hypermobility is an important clinical manifestation. We define the function of collagen V in tendons and ligaments, as well as the role of alterations in collagen V expression in the pathobiology in classic Ehlers-Danlos syndrome. A conditional Col5a1(flox/flox) mouse model was bred with Scleraxis-Cre mice to create a targeted tendon and...

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Identifiers

PMID: 25797646
DOI: 10.1016/j.ajpath.2015.01.031
PMCID: PMC4419209

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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