Article
Targeted deletion of collagen V in tendons and ligaments results in a classic Ehlers-Danlos syndrome joint phenotype.
The American journal of pathology - 1 May 2015
Sun Mei, Connizzo Brianne K, Adams Sheila M, Freedman Benjamin R, Wenstrup Richard J, Soslowsky Louis J, Birk David E
Abstract excerpt
Collagen V mutations underlie classic Ehlers-Danlos syndrome, and joint hypermobility is an important clinical manifestation. We define the function of collagen V in tendons and ligaments, as well as the role of alterations in collagen V expression in the pathobiology in classic Ehlers-Danlos syndrome. A conditional Col5a1(flox/flox) mouse model was bred with Scleraxis-Cre mice to create a targeted tendon and...
Topics
- Animals
- Biomechanical Phenomena
- Collagen Type V
- Disease Models, Animal
- Ehlers-Danlos Syndrome
- Gait
- Hand Strength
- Immunoblotting
- Immunohistochemistry
- Joints
- Ligaments
- Mice
- Mice, Knockout