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Article

Chronic Myelomonocytic Leukemia: History, Pathobiology, Diagnostic Controversies, and Evolving Classification.

Current hematologic malignancy reports - 3 Aug 2026

Loghavi Sanam, Hasserjian Robert P

Abstract excerpt

PURPOSE OF REVIEW: Chronic myelomonocytic leukemia (CMML) is a clonal myelodysplastic/myeloproliferative neoplasm characterized by sustained monocytosis, recurrent gene mutations, and a risk of transformation to acute myeloid leukemia (AML). This review examines the historical evolution of CMML as a diagnostic entity, its genetic landscape, fundamental controversies in definition, including the contentious...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42545651
DOI: 10.1007/s11899-026-00781-6
PMCID: PMC13433632

Genes

TET2
SF3B1
SRSF2
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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