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Article

Decoding circulating neutrophil phenotypes in triple-negative breast cancer via optimized single-cell RNA sequencing.

Cancer immunology, immunotherapy : CII - 19 May 2026

Banacki Marcin, Pastuszak Krzysztof, Sieczyński Michał, Suchodolska Grażyna, Senkus Elżbieta, Inkielewicz-Stepniak Iwona, Supernat Anna, Żaczek Anna

Abstract excerpt

Neutrophils are emerging as key regulators of tumor biology, influencing cancer progression, immune evasion, and therapeutic response. However, their transcriptomic characterization remains challenging due to low RNA content, limiting confident discrimination from other leukocyte populations at the single-cell level. To address this, we developed a robust analytical framework for single-cell RNA sequencing data,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42154046
DOI: 10.1007/s00262-026-04345-8
PMCID: PMC13388867

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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