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Article

Association of leptin gene polymorphisms (rs791620 and rs7799039) with rheumatoid arthritis susceptibility and clinical manifestations: a case-control study.

Clinical rheumatology - 1 Jul 2026

Hisham Fatma Azzahraa, Tharwat Samar, Nassar Dalia Kamal, Abdelsalam Sherehan A, Adel Yasmin, Nahas Mohamed M, Mostafa Nora, El-Desoky Manal M

Abstract excerpt

BACKGROUND AND AIMS: Leptin, an adipokine with immunomodulatory properties, has been implicated in rheumatoid arthritis (RA) pathogenesis. The aim of this study was to investigate the association of leptin (LEP) gene polymorphisms (rs791620 and rs7799039) with RA susceptibility, clinical characteristics, laboratory data, and musculoskeletal ultrasound (MSUS) findings in Egyptian patients. METHODS: This...

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Identifiers

PMID: 42151499
DOI: 10.1007/s10067-026-08169-w

Genes

LEP
CRP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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