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Article

Polymorphism in Leptin and Leptin Receptor Genes May Modify Leptin Levels and Represent Risk Factors for Multiple Sclerosis.

Immunological investigations - 1 May 2016

Farrokhi Mehrdad, Dabirzadeh Mehrnoosh, Fadaee Elyas, Beni Ali Amani, Saadatpour Zahra, Rezaei Ali, Heidari Zahra

Abstract excerpt

BACKGROUND: Leptin, the product of the ob gene, can modulate the immune responses and also seems to regulate Th1/Th2 balance by promoting a shift from the Th2 to the Th1 inflammatory cytokine pathway. Therefore, in this study, we aimed to investigate the association between polymorphisms of leptin gene (LEP) and leptin receptor gene (LEPR) and susceptibility to multiple sclerosis (MS). In addition, we...

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Source

Identifiers

PMID: 27105071
DOI: 10.3109/08820139.2016.1157811

Genes

LEP
LEPR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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