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Article

Cellular activation triggered by the autosomal dominant polycystic kidney disease gene product PKD2.

Molecular and cellular biology - 1 May 1999

Arnould T, Sellin L, Benzing T, Tsiokas L, Cohen H T, Kim E, Walz G

Abstract excerpt

Autosomal dominant polycystic kidney disease (ADPKD) is caused by germ line mutations in at least three ADPKD genes. Two recently isolated ADPKD genes, PKD1 and PKD2, encode integral membrane proteins of unknown function. We found that PKD2 upregulated AP-1-dependent transcription in human embryonic kidney 293T cells. The PKD2-mediated AP-1 activity was dependent upon activation of the mitogen-activated protein...

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Source

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Identifiers

PMID: 10207066
DOI: 10.1128/MCB.19.5.3423
PMCID: PMC84135

Genes

PKD2
PKD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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