Integrated single-cell multi-omics analysis identifies fibroblast-like smooth muscle cells as a key driving phenotypic switching during aortic aneurysm progression.

Abstract excerpt

BACKGROUND: Aortic aneurysm (AA) is a life-threatening vascular disorder characterized by smooth muscle cell (SMC) phenotypic switching. However, SMC heterogeneity and the regulatory mechanisms underlying this transition remain incompletely understood. METHODS: We integrated single-cell RNA sequencing (scRNA-seq) and single-cell assay for transposase-accessible chromatin sequencing (scATAC-seq) data from healthy...

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