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Article

Single-Cell Transcriptomic Profiling of Vascular Smooth Muscle Cell Phenotype Modulation in Marfan Syndrome Aortic Aneurysm.

Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 2020

Pedroza Albert J, Tashima Yasushi, Shad Rohan, Cheng Paul, Wirka Robert, Churovich Samantha, Nakamura Ken, Yokoyama Nobu, Cui Jason Z, Iosef Cristiana, Hiesinger William, Quertermous Thomas, Fischbein Michael P

Abstract excerpt

OBJECTIVE: To delineate temporal and spatial dynamics of vascular smooth muscle cell (SMC) transcriptomic changes during aortic aneurysm development in Marfan syndrome (MFS). Approach and Results: We performed single-cell RNA sequencing to study aortic root/ascending aneurysm tissue from Fbn1C1041G/+ (MFS) mice and healthy controls, identifying all aortic cell types. A distinct cluster of transcriptomically...

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Identifiers

PMID: 32698686
DOI: 10.1161/ATVBAHA.120.314670
PMCID: PMC7484233

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