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Article

Identification and functional assessment of CDSN gene variants associated with horn phenotypes in sheep.

BMC genomics - 14 May 2026

Hu Yangshuo, Zhang Min, Li Hao, He Xia, Meng Zhu, Zhang Shiwen, Liu Fei, Yang Huaiqiang, Zhu Jiada, Pan Zhangyuan, Liu Shen

Abstract excerpt

BACKGROUND: Horn phenotype is an important trait in sheep breeding, yet the genetic factors contributing to horn variation remain incompletely understood. In this study, we focused on the Corneodesmosin (CDSN) gene to evaluate its potential involvement in horn development and phenotypic divergence. RESULTS: Using RNA-seq data from horn tissue, we observed consistently higher CDSN expression in small-horn...

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PMID: 42135622
DOI: 10.1186/s12864-026-12888-4
PMCID: PMC13343795

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CDSN

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